L-methylfolate: a vitamin for your monoamines.
نویسنده
چکیده
Synthesis of the monoamine neurotransmitters serotonin, dopamine, and norepinephrine is regulated by L-methylfolate, a derivate of the vitamin folate.
منابع مشابه
Methylfolate Trap Promotes Bacterial Thymineless Death by Sulfa Drugs
The methylfolate trap, a metabolic blockage associated with anemia, neural tube defects, Alzheimer's dementia, cardiovascular diseases, and cancer, was discovered in the 1960s, linking the metabolism of folate, vitamin B12, methionine and homocysteine. However, the existence or physiological significance of this phenomenon has been unknown in bacteria, which synthesize folate de novo. Here we i...
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Rats exposed to N20 show a decrease in liver folate to about 25% of the initial value after 10 days. There is a transient increase in the amount of 5-methylterrahydropteroylpolyglutamate in the first 24 h, but thereafter the content decreases. The level of 5-methyltetrahydropterolymonoglutamate declines without any transitory increase. The transient accumulation of 5-methyltetrahydropteroylpoly...
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The [c-lactam] derivative of cobalamin antagonizes vitamin B12 in vivo. Therefore, we investigated its effects in tissue culture to develop a model in which to study vitamin B12-deficient hemopoiesis. HL60 cells were cultured in medium containing either methionine or L-homocysteine thiolactone, and various concentrations of 5-methyltetrahydrofolate or pteroylglutamic acid. In medium with L-homo...
متن کاملEffect of adjunctive L-methylfolate 15 mg among inadequate responders to SSRIs in depressed patients who were stratified by biomarker levels and genotype: results from a randomized clinical trial.
OBJECTIVE Specific genetic or biological markers may predict inadequate response to therapy for major depressive disorder (MDD). The objective of the current post hoc analysis was to evaluate the effect of specific biological and genetic markers on the antidepressant efficacy of adjunctive L-methylfolate 15 mg versus placebo from a trial of inadequate responders to selective serotonin reuptake ...
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1. DNA synthesis in the bone marrow and lymphocytes of the vitamin B12-deficient fruit bat (Rosettus Aegyptiacus) has been studied via the deoxyuridine (dU) suppression test. 2. In contrast to vitamin B12 deficiency in man, the dU suppression test was not abnormal in the vitamin B12-deficient bat, and this correlates with the reported finding that the latter does not develop megaloblastic anaem...
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ورودعنوان ژورنال:
- The Journal of clinical psychiatry
دوره 69 9 شماره
صفحات -
تاریخ انتشار 2008